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OxLDL also plays a pro-inflammatory role by stimulating endothelial cells to express adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) [71]
Mice with Y2R knockout in the hypothalamus have increased osteoblastic activity, mineralization rate, and bone mass, indicating that Y2R normally plays a catabolic role in stimulating cortical and cancellous bone formation [77]
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